4 RESULTS
COMMENT It’s an interesting hypothesis, but more especially for Parkinson’s disease (PD) than AD. The pathogenesis of vitiligo encompasses both melanocyte vulnerability and autoimmunity by interferon-γ-producing, melanocyte-specific CD81 T cells, and melanized ne
COMMENT We have assessed the evidence for TMEM230 mutations as a cause of Parkinson's disease, and question the validity of the original work by Deng and colleagues, 2016. We conclude 'TMEM230 is NOT a gene for Parkinson's disease' (see bioRχi
COMMENT This study raises some intriguing possibilities. Loss of retromer expression has long been noted in AD, with consequent effects on APP processing and Aβ production. However, retromer recycling appears as a nexus for parkinsonism and dementia. Deficits in
COMMENT Pablo Sardi and colleagues did an excellent job describing the GBA mouse model; however, the data/experimental design could not decipher the central conundrum, i.e., whether GBA mutations act through a loss of function or a toxic gain of function. The aut
